Pancreatic Cancer HPAF/CD18 cells: Ecd knockdown vs Scrambled

ABSTRACT: Purpose: To study the expression and function of a novel cell cycle regulatory protein, human ecdysoneless (Ecd), during pancreatic cancer (PC) pathogenesis. Experimental Design: Immunohistochemical expression profiling of Ecd was done in non-neoplastic normal pancreatic tissues and pancreatic ductal adenocarcinoma lesions (from tissue microarray and Rapid Autopsy program) as well as precancerous PanIN lesions and metastatic organs. To analyze the biological significance of Ecd in PC progression, Ecd was stably knocked down in PC cell line followed by in vitro and in vivo functional assays. Results: Normal pancreatic ducts show very weak to no Ecd expression compared to significant positive expression in PC tissues (mean±SE composite score: 0.3±0.2 and 3.8±0.2 respectively, p<0.0001) as we

ORGANISM(S): Homo sapiens

SUBMITTER: Parama Dey 

PROVIDER: E-GEOD-39988 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress