RNA sampling from a chemically diverse set of solid agar cultures of Aspergillus nidulans

ABSTRACT: In this study, we design and apply a DNA expression array for Aspergillus nidulans in combination with legacy data to form a comprehensive gene expression compendium. We apply a guilt-by-association-based analysis to predict the extent of the biosynthetic clusters for the 58 synthases active in our set of experimental conditions. A comparison with legacy data shows the method to be accurate in 13 out of 16 known clusters and nearly accurate for the remaining three. Furthermore, we apply a data clustering approach, which identifies cross-chemistry between physically separate gene clusters (super clusters), and validate this both with legacy data and experimentally by prediction and verification of a new supercluster consisting of the synthase AN1242 and the transferase AN11080. This normall

ORGANISM(S): Emericella nidulans

SUBMITTER: Mikael Andersen 

PROVIDER: E-GEOD-39993 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress