Gene expression characterization of HPV positive head and neck cancer to predict response to Chemoradiation

ABSTRACT: Background: Human papillomavirus has been shown to have a causal role in the development of head and neck squamous cell carcinoma and represents a distinct and well-defined pathology. While HPV-positive HNSCC is associated with a better response to treatment and prognosis, a subset of patients do not respond favorably to current standard of care thus suffering unnecessary morbidity and delay to receive effective therapy. Methods: RNA from nineteen patients with HPV-positive HNSCC was subjected to gene expression analysis using Affymetrix microarrays. HPV-status was confirmed by detection of HPV16 E7 with RT-PCR. Results: In addition to specific genetic biomarkers (including LCE3D, KRTDAP, HMOX1, KRT19, MDK, TSPAN1), differentially expressed genes were highly represented in the cell process

ORGANISM(S): Homo sapiens

SUBMITTER: Bryan Thibodeau 

PROVIDER: E-GEOD-40020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress