Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Hongjuan Zhao
PROVIDER: E-GEOD-4010 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhao Hongjuan H Lai Frank F Nonn Larisa L Brooks James D JD Peehl Donna M DM
The Prostate 20050301 4
<h4>Background</h4>We used cDNA microarray analysis to obtain insights into the mechanisms of action of doxazosin, an alpha(1)-adrenergic receptor antagonist used to treat benign prostatic hyperplasia (BPH).<h4>Methods</h4>Hierarchical clustering analysis and significance analysis of microarray (SAM) were performed to identify genes differentially expressed between untreated stromal cells cultured from normal tissue and BPH, and changes in gene expression induced by doxazosin. Transcript levels ...[more]