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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Amacr knock-out mouse liver and intestine

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Kaija Autio

PROVIDER: E-GEOD-40125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phytol is lethal for Amacr-deficient mice.

Selkälä Eija M EM Nair Remya R RR Schmitz Werner W Kvist Ari-Pekka AP Baes Myriam M Hiltunen J Kalervo JK Autio Kaija J KJ

Biochimica et biophysica acta 20150804 10

α-Methylacyl-CoA racemase (Amacr) catalyzes the racemization of the 25-methyl group in C27-intermediates in bile acid synthesis and in methyl-branched fatty acids such as pristanic acid, a metabolite derived from phytol. Consequently, patients with Amacr deficiency accumulate C27-bile acid intermediates, pristanic and phytanic acid and display sensorimotor neuropathy, seizures and relapsing encephalopathy. In contrast to humans, Amacr-deficient mice are clinically symptomless on a standard labor ...[more]

PMID: 26248199

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Expression data from Amacr knock-out mouse intestine

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