Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation

ABSTRACT: Synthetic, innate defense regulators (IDR) peptides, designed based on natural host defenses peptides, have enhanced immunomodulatory activities and reduced toxicity leading to protection in infection and inflammation models that is dependent on macrophages/monocytes. Here we measured the effect of IDR-1018 on macrophage gene expression during differentiation. Differentiation in the presence of IDR-1018 induced a unique signature of immune responses suggesting that IDR-1018 drives macrophage differentiation towards an intermediate M1-M2 state, enhancing anti-inflammatory functions while maintaining certain pro-inflammatory activities important to the resolution of infection. RNA-seq was performed using the Illumina Genome Analyzer IIx platform. Monocytes were isolated from 3 healthy donors

ORGANISM(S): Homo sapiens

SUBMITTER: Christopher Fjell 

PROVIDER: E-GEOD-40131 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress