Regulatory impact of RNA secondary structure across the Arabidopsis thaliana transcriptome

ABSTRACT: The secondary structure of an RNA molecule plays an integral role in its maturation, regulation, processing, and functionality. However, the global influence of this feature on plant gene expression is still for the most part unclear. Here, we use a high-throughput, sequencing-based, structure-mapping approach in conjunction with transcriptome-wide sequencing of polyA+-selected (RNA-seq), small (smRNA-seq), and ribosome-bound (ribo-seq) RNA populations to investigate the impact of RNA secondary structure on gene expression regulation in Arabidopsis. From this analysis, we find that highly unpaired and paired RNAs are strongly correlated with euchromatic and heterochromatic epigenetic histone modifications, respectively, providing further evidence that secondary structure is necessary for R

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Fan Li 

PROVIDER: E-GEOD-40209 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress