Unknown,Transcriptomics,Genomics,Proteomics

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The Stockholm Atherosclerosis Gene Expression (STAGE) study: Global Gene Expression data from coronary and carotid artery disease patients

ABSTRACT: Tissue samples have been isolated during corornary artery by-pass grafting (CABG)surgery from the atheroscelrotic arterial wall (AAW, aortic root puncture for proxmal ligation of by-pass vessel), non-atherosclertoci arterial wall (NAAW, distal part of mammary artery used a graft for LAD), liver, skeletal muscle (Recturs m), pericardial mediastinal visceral fat) in CAD patients. Carotid lesions samples from 25 validation patients. We used microarrays to measure global gene expression in these tissues to cluster groups of functionally associated genes and then, second step clustering of patients within each cluster to link clusters to patient phenotypes primarily coronary stenosis (CAD) and Intima media thickness (IMT) in carotid stenosis patients. . All samples were taken during surgery. The time of operation was less than 3 hours in most instances. Sammon plots show strong clustering of tissue-specific arrays. Even separating AAW from NAAW and carotid lesions.

ORGANISM(S): Homo sapiens

SUBMITTER: Johan Björkegren 

PROVIDER: E-GEOD-40231 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Multi-organ expression profiling uncovers a gene module in coronary artery disease involving transendothelial migration of leukocytes and LIM domain binding 2: the Stockholm Atherosclerosis Gene Expression (STAGE) study.

Hägg Sara S   Skogsberg Josefin J   Lundström Jesper J   Noori Peri P   Nilsson Roland R   Zhong Hua H   Maleki Shohreh S   Shang Ming-Mei MM   Brinne Björn B   Bradshaw Maria M   Bajic Vladimir B VB   Samnegård Ann A   Silveira Angela A   Kaplan Lee M LM   Gigante Bruna B   Leander Karin K   de Faire Ulf U   Rosfors Stefan S   Lockowandt Ulf U   Liska Jan J   Konrad Peter P   Takolander Rabbe R   Franco-Cereceda Anders A   Schadt Eric E EE   Ivert Torbjörn T   Hamsten Anders A   Tegnér Jesper J   Björkegren Johan J  

PLoS genetics 20091204 12

Environmental exposures filtered through the genetic make-up of each individual alter the transcriptional repertoire in organs central to metabolic homeostasis, thereby affecting arterial lipid accumulation, inflammation, and the development of coronary artery disease (CAD). The primary aim of the Stockholm Atherosclerosis Gene Expression (STAGE) study was to determine whether there are functionally associated genes (rather than individual genes) important for CAD development. To this end, two-w  ...[more]