Milbemycins: more than efflux inhibitors for fungal pathogens

ABSTRACT: This study investigated the effect of milbemycons as efflux inhibitors and antifungal agents. Milbemycin oxims can inhibit growth of Candida glabrata and C. albicans. The effect of milbemycins on transcriptomes was inbvestigated. Gene expression was measured in C. glabrata milbemycin-treated cells (1h) and compared to untreated cells in the incubation mediun RPMI. The one-color system was used. Four biological replicates were used for each condition. Gene expression was measured in C. albicans milbemycin-treated cells (1h) and compared to untreated cells in the incubation mediun RPMI. The one-color system was used. Three biological replicates were used for each condition.

ORGANISM(S): Candida albicans

SUBMITTER: Dominique Sanglard 

PROVIDER: E-GEOD-40232 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress