Bladder cancer: analysis of miRNA-mRNA interactions

ABSTRACT: Background: MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Their abilyty to affect multiple gene pathways by targeting to various mRNAs makes them to an interesting class of regulators. The interplay between miRNA and mRNA has been proposed as an important process in cancer development and progression. In this study, we analyzed miRNA -mRNA interactions in bladder urothelial carcinoma. Methodology/Principal Findings: We have developed a new algorithm which is capable of identifying altered miRNA-mRNA regulation between tissues samples without preexisting stratification of groups. Microarray expression profiling of both miRNA and mRNA from the same sample were performed using a collective of 24 urothelial carcinoma and normal bladder tissue samples. Using our ap

ORGANISM(S): Homo sapiens

SUBMITTER: Hellmuth-A Meyer 

PROVIDER: E-GEOD-40355 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress