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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic

ABSTRACT: We conducted whole-genome expression profiling on 101 pairs of ccRCC tumours and adjacent non-tumour renal tissue from Czech patients using the Illumina HumanHT-12 v4 Expression BeadChips to explore the molecular variations underlying the biological and clinical heterogeneity of ccRCC. Total RNA obtained from frozen ccRCC tumour and adjacent non-tumour renal tissue.

ORGANISM(S): Homo sapiens

SUBMITTER: Magdalena Wozniak

PROVIDER: E-GEOD-40435 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States.

Wozniak Magdalena B MB Le Calvez-Kelm Florence F Abedi-Ardekani Behnoush B Byrnes Graham G Durand Geoffroy G Carreira Christine C Michelon Jocelyne J Janout Vladimir V Holcatova Ivana I Foretova Lenka L Brisuda Antonin A Lesueur Fabienne F McKay James J Brennan Paul P Scelo Ghislaine G

PloS one 20130305 3

Gene expression microarray and next generation sequencing efforts on conventional, clear cell renal cell carcinoma (ccRCC) have been mostly performed in North American and Western European populations, while the highest incidence rates are found in Central/Eastern Europe. We conducted whole-genome expression profiling on 101 pairs of ccRCC tumours and adjacent non-tumour renal tissue from Czech patients recruited within the "K2 Study", using the Illumina HumanHT-12 v4 Expression BeadChips to exp ...[more]

PMID: 23526956

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