Mechanisms and rescue strategies of Calcineurin inhibitor mediated tolerance abrogation

ABSTRACT: To ensure safety tolerance induction protocols are accompanied by conventional immunosuppressive drugs IS. But IS such as calcineurin inhibitors CNI can interfere with tolerance induction. We investigated the effect of an additional CNI treatment on anti-CD4 mAb-induced tolerance induction upon rat kidney transplantation. Additional CNI treatment induced deteriorated graft function and chronic rejection characterised by alloantibody production, intragraft plasma cells and C3d deposition. Microarray analysis revealed enhanced intragraft expression of the B cell chemokine CXCL13 upon additional CNI treatment. In contrast PNOC, a B cell-related gene highly expressed in operational tolerant kidney transplant recipients, was decreased in grafts of anti-CD4 mAb+CsA-treated recipients suggestin

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bernhard Gerstmayer 

PROVIDER: E-GEOD-40454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress