STATs Shape the Active Enhancer Landscape of T Cell Populations

ABSTRACT: Signaling pathways are intimately involved in cellular differentiation, allowing cells to respond to their environment by regulating gene expression. While enhancers are recognized as key elements that regulate selective gene expression, the interplay between signaling pathways and actively used enhancer elements is not clear. Here, we use CD4+ T cells as a model of differentiation, mapping the acquisition of cell-type-specific enhancer elements in T-helper 1 (Th1) and Th2 cells. Our data establish that STAT proteins have a major impact on the acquisition of lineage-specific enhancers and the suppression of enhancers associated with alternative cell fates. Transcriptome analysis further supports a functional role for enhancers regulated by STATs. Importantly, expression of lineage-defining

ORGANISM(S): Mus musculus

SUBMITTER: Golnaz Vahedi 

PROVIDER: E-GEOD-40463 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress