The temporal dynamics of proinflammatory and immuno-regulatory processes during progression to type 1 diabetes in the BioBreeding rat [rat]

ABSTRACT: A need exists for biomarkers in T1D that can 1) sensitively and specifically detect disease-related immune activity prior to, and independent of, measurement of auto-antibodies towards islet cell antigens; 2) define immunopathological mechanisms; and 3) monitor changes in the inflammatory state associated with disease progression or response to therapeutic intervention. In an effort to fill this gap, we have applied a novel bioassay to both human and BB rat T1D whereby the complex milieu of inflammatory mediators present in plasma can be indirectly detected through their ability to drive transcription in peripheral blood mononuclear cells (PBMCs) drawn from healthy, unrelated donors. The resultant gene expressions are comprehensively measured with a microarray. In our human studies, we

ORGANISM(S): Rattus norvegicus

SUBMITTER: Martin Hessner 

PROVIDER: E-GEOD-40497 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress