MiR-10b*, a master inhibitor of the cell cycle, is downregulated in human breast tumors

ABSTRACT: Deciphering the molecular mechanisms involved in breast tumorigenesis has been the subject of extensive research in the last years; yet unpredictable response and development of resistance to adjuvant therapies remain major questions in the management of breast cancer patients. The power of miR expression signatures has emerged recently from several studies. Normal and breast tumor tissues can be discriminated by a miR signature as reported by Iorio et al (Iorio et al, 2005). Recent findings have also linked deregulated miR expression to breast cancer metastasis (Adorno et al, 2009; Huang et al, 2008; Tavazoie et al, 2008). Moreover, microRNAs are considering as a powerful tool in diagnosis and prognosis of breast cancer. In our study, we measured microRNA expression profiles from 64 prima

ORGANISM(S): Homo sapiens

SUBMITTER: Noa Bossel 

PROVIDER: E-GEOD-40525 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress