Expression Analysis of Whole Thymus and Thymic Tumors on the Sdl Mouse Model

ABSTRACT: Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance; while mice homozygous for the mutation die early during embryonic development. Sdl mice harbor increased numbers of spontaneous micronuclei, and Sdl T-ALLs harbor small amplifications and deletions, including activating deletions at the Notch1 locus. Sdl mice harbor a spontaneously acquired mutation in Mcm4 (Mcm4D573H). MCM4 is part of the heterohexameric complex of MCM2-7 that is important for licensing of DNA origins prior to S phase and also serves as the core of the replicative helicase that unwinds DNA at the replication fork. This exon array was conducted

ORGANISM(S): Mus musculus

SUBMITTER: Bruce Bagley 

PROVIDER: E-GEOD-40527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress