Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation

ABSTRACT: The aim of the dataset was to study on genome-wide level the effect of PIM kinase (PIM1+PIM2+PIM3) knockdown in gene expression on early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) polarizing conditions. Total RNA from PIM1+PIM2+PIM3 siRNA treated cord blood CD4+ T cells 6 hours after culturing the cells in activating (antiCD3+antiCD28) plus IL-12 (Th1) or IL-4 (Th2) conditions was compared to total RNA from nonspecific control siRNA treated cells. Samples from 3 biological replicates were analysed.

ORGANISM(S): Homo sapiens

SUBMITTER: Kartiek Kanduri

PROVIDER: E-GEOD-40542 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

Tahvanainen Johanna J Kyläniemi Minna K MK Kanduri Kartiek K Gupta Bhawna B Lähteenmäki Hanna H Kallonen Teemu T Rajavuori Anna A Rasool Omid O Koskinen Päivi J PJ Rao Kanury V S KV Lähdesmäki Harri H Lahesmaa Riitta R

The Journal of biological chemistry 20121203 5

The differentiation of human primary T helper 1 (Th1) cells from naïve precursor cells is regulated by a complex, interrelated signaling network. The identification of factors regulating the early steps of Th1 cell polarization can provide important insight in the development of therapeutics for many inflammatory and autoimmune diseases. The serine/threonine-specific proviral integration site for Moloney murine leukemia virus (PIM) kinases PIM1 and PIM2 have been implicated in the cytokine-depen ...[more]

PMID: 23209281

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Dataset Information

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation

Publications

Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation.

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