Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ORNL Hr(Rh-R) mouse cutaneous array

ABSTRACT: These data is from 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice. Mouse 15k microarray from the Center for Applied Genomics was used to survey the gene expression. The data was acquired with ImaGene and processed with GeneSight from BioDiscovery. Keywords: Genetic mutants Three pairs of littermates from one liter, 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice, were used for the hybridization. Dye-swapping was done for each pair of littermates.

ORGANISM(S): Mus musculus

SUBMITTER: Yutao Liu

PROVIDER: E-GEOD-4055 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Molecular basis for hair loss in mice carrying a novel nonsense mutation (Hrrh-R ) in the hairless gene (Hr).

Liu Y Y Sundberg J P JP Das S S Carpenter D D Cain K T KT Michaud E J EJ Voy B H BH

Veterinary pathology 20100101 1

Animal models carrying mutations in the hairless (Hr) gene provide a rich resource for study of hair follicle biology. A spontaneous mouse mutant with a phenotype strikingly similar to rhino mutants of Hr arose spontaneously in the mouse facility at Oak Ridge National Laboratory. Sequence analysis of Hr in these mutants uncovered a nonsense mutation in exon 12, designated as Hr(rh-R) (rhino, Oak Ridge). The mutation led to significant reduction in Hr mRNA levels, predicted to be due to nonsense- ...[more]

PMID: 20080498

Similar Datasets

ORNL Hr(Rh-R) mouse cutaneous array

Project description:These data is from 10 day-old Hr(Rh-R)/Hr(Rh-R) vs Hr(Rh-R)/+ mice. Mouse 15k microarray from the Center for Applied Genomics was used to survey the gene expression. The data was acquired with ImaGene and processed with GeneSight from BioDiscovery. Keywords: Genetic mutants

2006-04-18 | GSE4055 | GEO

ORNL 5wk Hr(n)/+ mice skin array

Project description:This array is spotted in house in order to survey the interested genes expressed mainly in skin with the selection of the clones from Research Genetics. Keywords: Genetic Mutant 5 week-old heterozygous Hr(n) mutant mice vs wild-type mice was used in the microarray. Four biological replicates were included from the same litter. Dye swapping was done to control dye-specific errors. The data was analyzed with ImaGene and GeneSight from BioDiscovery.

2010-07-01 | E-GEOD-4053 | biostudies-arrayexpress

Near naked hairless, Hr(n), and Hr(Rh-R) mice

Project description:This SuperSeries is composed of the following subset Series: GSE4052: Near Naked Hairless mouse skin array GSE4053: ORNL 5wk Hr(n)/+ mice skin array GSE4055: ORNL Hr(Rh-R) mouse cutaneous array Keywords: SuperSeries Refer to individual Series

2010-07-01 | E-GEOD-4059 | biostudies-arrayexpress

Near Naked Hairless mouse skin array

Project description:This is the data from 7 day-old homozygous Hrn mutant mice compared to the wild type mice with mouse 22k compugen oligolibrary 2.0. The data was normalized with GeneSight from BioDiscovery and analyzed with SAM. Keywords: Genetic mutant 7 day-old near naked hairless mutant mice vs 7 day-old wild type mice. Five biological replicates were used from one litter. Dye-swapping was done to remove dye-specific errors

2010-07-01 | E-GEOD-4052 | biostudies-arrayexpress

Parasite gene expression differences between RH-ERP, RH-JSR and GT1 of Toxoplasma gondii.

Project description:Parasite gene expression differences have been reported previously between RH-ERP, RH-JSR and GT1. To independently confirm these gene expression differences, we examined the parasite gene expression profiles of RH-ERP, RH-JSR and GT1 through microarray.

2013-08-20 | GSE44191 | GEO

Global gene expression differences between GT1, RH-ERP2009 and RH-JSR

Project description:Previous studies have shown that continuous in vitro passage can result in changes to the global gene expression profiles in mammalian cells. To examine the extent of gene expression differences between highly homologous type I strains, we took advantage of the T. gondii Affymetrix microarray containing probes to more than 8,000 genes. We compared the RH-JSR and GT1 strains, two isolates that share the small plaque phenotype, to the large plaque isolate RH-ERP2009. Following hybridization and normalization of data, we used two independent methods to generate lists of genes with expression differences that were statistically significant and 2-fold or greater in at least one sample. The 1-way ANOVA (P ≤ 0.05) identified 520 genes that were significantly differentially expressed between GT1, RH-ERP2009 and RH-JSR. Statistical Analysis of Microarray (SAM) (FDR = .05%) analysis identified 475 transcripts that were differentially expressed. Both lists were combined (610 genes) and used to perform pairwise fold comparisons between the three samples. This process identified 113 genes that were similarly expressed in GT1 and RH-JSR and differentially expressed in RH-ERP2009. Differentially expressed genes were located across all chromosomes and showed no pattern of clustering to one particular region of the genome. Interestingly, three out of 34 ABC transporters (ToxoDB) were significantly upregulated in RH-ERP2009 (hypergeometric distribution, P = 0.01)

2009-10-26 | GSE16115 | GEO

Toxoplasma gondii RH strain:RH

Project description:Toxoplasma gondii RH strain:RH Genome sequencing

| PRJNA238965 | ENA

Near Naked Hairless mouse skin array

2006-04-18 | GSE4052 | GEO

Host gene expression response to Toxoplasma gondii infection is not different between RH∆ku80 and RH∆ku80∆rop5 parasites

Project description:The normally virulent type-I RH parasite is rendered avirulent when lacking ROP5. The avirulent phenotype is a consequence of interaction with the host innate immune system. We sought to understand if ROP5 alters host gene expression in order to escape host defenses. We saw no gene expression differences between host cells infected with wt (RH∆ku80) or RH∆ku80∆rop5 parasites. We have included uninfected HFF samples that were harvested in parallel with the infected samples.

2012-09-13 | GSE32104 | GEO

Effect of Rh(III) on gene expression in HeLa cell line

Project description:We designed a highly emissive rhodium(III) complex ( Rh(III) complex) as the mtDNA intercalator. Rh(III) complex can specifically bind to mtDNA to cause the cytoplasmic release of mtDNA fragments to activate the cGAS-STING pathway. Moreover, Rh(III) complex activates the mitochondrial retrograde signaling by disturbing the key metabolites. Herein,we performed RNA-seq to illustrate the function of Rh(III) complex on HeLa cells. RNA-seq was performed on HeLa cells, which were treated by 1% DMSO or Rh(III) complex (1 uM, 6h), respectively.

2023-07-06 | GSE221227 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data