DNA microarray analysis of labial salivary glands in IgG4-related disease M-bM-^@M-^S comparison with SjM-CM-6grenM-bM-^@M-^Ys syndrome

ABSTRACT: To compare gene expression in labial salivary glands (LSG) of IgG4-related disease (IgG4-RD) with SjM-CM-6grenM-bM-^@M-^Ys syndrome (SS). Gene expression was analyzed by DNA microarray in LSG of IgG4-RD (n=5), SS (n=5), and healthy controls (n=3). Differentially expressed genes (DEGs) in IgG4-RD and SS were identified, and gene-annotation enrichment analysis of these DEGs was performed using Gene Ontology (GO) annotation. Validation of the result was performed by quantitative PCR using LSG from IgG4-RD (n=9), SS (n=10), and controls (n=4). Gene expression patterns in IgG4-RD, SS, and healthy controls were quite different with each other in hierarchical clustering as well as principal component analysis. In IgG4-RD, 1771 up-regulated probe sets (corresponding

ORGANISM(S): Homo sapiens

SUBMITTER: Yuji Nakai 

PROVIDER: E-GEOD-40568 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress