The RNA-binding protein FXR1P regulates cell-cycle progression by modulating the expression of p21/cdkn1a/Cip1/Waf in myoblasts

ABSTRACT: The Fragile X Mental Retardation-Related 1 gene (FXR1) belongs to the Fragile X Related gene family, together with FMR1 and FXR2. While inactivation of FMR1 causes Fragile X syndrome, the most common form of inherited mental retardation, inactivation of FXR1 in various animal models suggest a critical role for the RNA-binding protein FXR1P during myogenesis. Seven alternatively spliced FXR1 transcripts have been identified, three of them being muscle-specific. We previously reported a reduction of these isoforms in myoblasts from Fascio Scapulo Humeral Distrophy (FSHD) myopathic patients. However, so far, no mRNA target of FXR1P has been linked to the drastic muscular phenotypes caused by its absence and the exact molecular role of FXR1P in muscular development remains unknown. In the pres

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lebrigand 

PROVIDER: E-GEOD-40577 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress