Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme

ABSTRACT: Glioblastoma multiforme (GBM) is the most common form of malignant glioma and is characterized by marked genetic instability, extensive intra-tumoral histopathological variability, and unpredictable variation in its clinical behavior. We investigated global gene expression in surgical samples of primary brain tumors. Gene expression profiling revealed large differences between normal brain samples and tumor tissues and between GBMs and lower grade oligodendroglial tumors. Extensive differences in gene expression were found among GBMs, particularly in genes involved in angiogenesis, immune cell infiltration, and extracellular matrix re-modeling. Significantly, we found that the global gene expression patterns in paired specimens from the same GBM invariably were more closely related to each

ORGANISM(S): Homo sapiens

SUBMITTER: Max Diehn 

PROVIDER: E-GEOD-4058 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress