Peripheral blood RNA gene expression profiling in patients with bacterial meningitis

ABSTRACT: The aim of present study was to describe the genetic pathways activated during the community acquired bacterial meningitis (BM) by using genome-wide RNA expression profiling combined with functional annotation of transcriptional changes. We included 21 patients with BM hospitalized in 2008. The control group consisted of 18 healthy subjects. The RNA was extracted from whole blood, globin mRNA was depleted and gene expression profiling was performed with GeneChip Human Gene 1.0 ST Arrays enabling the analysis of 28,869 genes. Gene expression profile data were analyzed using Bioconductor packages and Bayesian modeling. Functional annotation of the enriched gene sets was used to define changed genetic networks. We also analyzed if the gene expression profile depends on the clinical course and

ORGANISM(S): Homo sapiens

SUBMITTER: Sulev Koks 

PROVIDER: E-GEOD-40586 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress