Role of a GntR-family response regulator LbrA in Listeria monocytogenes biofilm formation

ABSTRACT: The formation of Listeria monocytogenes biofilms contributes to persistent contamination in food processing facilities. A microarray comparison of L. monocytogenes between the transcriptome of the strong biofilm forming strain (Bfms) Scott A and the weak biofilm forming (Bfmw) strain F2365 was conducted to identify genes potentially involved in biofilm formation. Among 951 genes with significant difference in expression between the two strains, a GntR-family response regulator encoding gene (LMOf2365_0414), designated lbrA, was found to be highly expressed in Scott A relative to F2365. A Scott A lbrA-deletion mutant, designated AW3, formed biofilm to a much lesser extent as compared to the parent strain by a rapid attachment assay and scanning electron microscopy. Complementation with lbr

ORGANISM(S): Listeria monocytogenes

SUBMITTER: Lu Zhang 

PROVIDER: E-GEOD-40598 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress