Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cornelis Verweij
PROVIDER: E-GEOD-4061 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.
Kasperkovitz Pia V PV Timmer Trieneke C G TC Smeets Tom J TJ Verbeet Nicolette L NL Tak Paul P PP van Baarsen Lisa G M LG Baltus Belinda B Huizinga Tom W J TW Pieterman Elsbet E Fero Mike M Firestein Gary S GS van der Pouw Kraan Tineke C T M TC Verweij Cornelis L CL
Arthritis and rheumatism 20050201 2
<h4>Objective</h4>Given the heterogeneity of gene expression patterns and cellular distribution between rheumatoid arthritis (RA) synovial tissues, we sought to determine whether this variability was also reflected at the level of the fibroblast-like synoviocyte (FLS) cultured from RA synovial tissues.<h4>Methods</h4>Gene expression profiles in FLS cultured from synovial tissues obtained from 19 RA patients were analyzed using complementary DNA microarrays and hierarchical cluster analysis. To v ...[more]
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