EGF decreases the abundance of microRNAs that restrain oncogenic transription factors

ABSTRACT: Epidermal growth factor (EGF) stimulates cells by launching gene expression programs that are frequently deregulated in cancer. MicroRNAs, which attenuate gene expression by binding complementary regions in messenger RNAs, are broadly implicated in cancer. Using genome-wide approaches, we showed that EGF stimulation initiates a coordinated transcriptional program of microRNAs and transcription factors. The earliest event involved a decrease in the abundance of a subset of 23 microRNAs. This step permitted rapid induction of oncogenic transcription factors, such as c-FOS, encoded by immediate early genes. In line with roles as suppressors of EGF receptor (EGFR) signaling, we report that the abundance of this early subset of microRNAs is decreased in breast and in brain tumors driven by the

ORGANISM(S): Homo sapiens

SUBMITTER: roi avraham 

PROVIDER: E-GEOD-40626 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress