Does Type of Dietary Fat Matter? Prostate Cancer Xenograft Progression in a SCID Mouse Model with Varying Dietary Fat Sources

ABSTRACT: PURPOSE: Previous mouse studies using corn oil (Ï?-6) as the dietary fat source suggest that decreasing dietary fat content can slow prostate cancer (PCa) growth. However, other studies, in which the diet was composed around saturated fat, showed no difference in outcomes between high-fat and low-fat diets. The relative effects of other fats, such as fish oil and olive oil, also remain unexplored. To our knowledge, no trial has yet compared the effect of various fats on prostate cancer progression. Therefore, we sought to systematically study the effect of fish oil, olive oil, corn oil, and saturated fat on prostate cancer progression. METHODS: A total of 96 male SCID mice were injected with LAPC-4 human PCa cells. Two weeks following injection, mice were singly-housed and randomiz

ORGANISM(S): Homo sapiens

SUBMITTER: Jen-Tsan Chi 

PROVIDER: E-GEOD-40654 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress