Carbohydrates Regulate Virulence Gene Expression in Streptococcus suis

ABSTRACT: Streptococcus suis is a major pig pathogen as well as an emerging zoonotic pathogen. Previous work has demonstrated that the S. suis extracellular amylopullulanase enzyme (ApuA) that degrades {alpha}-glucans also functions as an adhesin for porcine epithelial cells. To identify the mechanisms linking carbohydrate metabolism and virulence, we first compared the transcriptome of S. suis in minimal medium supplemented with glucose to minimal medium containing a complex carbohydrate pullulan as a carbon source. The relative expression of eighteen virulence genes including suilysin and apuA was increased during growth in presence of pullulan, compared to growth in glucose. Increased virulence potential of S. suis grown in pullulan was demonstrated using hemolytic assays and increased adhesion a

ORGANISM(S): Streptococcus suis P1/7

SUBMITTER: Peter van Baarlen 

PROVIDER: E-GEOD-40658 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress