Comparison of Renca tumor cells growing intrakidney or subcutaneously

ABSTRACT: Tumors can occur in many sites in the body, but how tissues at different anatomical sites affect tumor microenvironments and their subsequent response to therapy is not known. Here we show that different tissues can cause the same tumor to develop fundamentally different microenvironments resulting in dramatic changes in responses to immunotherapy. Whereas established subcutaneous tumors could be eradicated in the majority of mice using a combination of three agonist antibodies, tumors in visceral organs responded much less. Orthotopic kidney tumors had a microenvironment with a higher frequency of alternatively-activated macrophages and their associated molecules. Neutralizing the CCL2 chemokine or IL-13 cytokine, important in macrophage biology led to a greatly improved therapeutic effec

ORGANISM(S): Mus musculus

SUBMITTER: Michael Kershaw 

PROVIDER: E-GEOD-40679 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress