Foxp3 exploits a preexistent enhancer landscape for regulatory T cell lineage specification [Expression]

ABSTRACT: Regulatory T (Treg) cells, whose identity and function are defined by the transcription factor Foxp3, are indispensable for immune homeostasis. It is unclear whether Foxp3 exerts its Treg lineage specification function through active modification of the chromatin landscape and establishment of new enhancers or by exploiting a pre-existing enhancer landscape. Analysis of the chromatin accessibility of Foxp3-bound enhancers in Treg and Foxp3-negative T cells showed that Foxp3 was bound overwhelmingly to pre-accessible enhancers occupied by its cofactors in precursor cells or a structurally related predecessor. Furthermore, the bulk of Foxp3-bound Treg cell enhancers inaccessible in Foxp3- CD4+ cells became accessible upon T cell receptor activation prior to Foxp3 expression with only a sma

ORGANISM(S): Mus musculus

SUBMITTER: Aaron Arvey 

PROVIDER: E-GEOD-40685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress