Gene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)

ABSTRACT: The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer in man. The MaCSCs are capable of recapitulating tumorigenesis when transplanted at low multiplicities in vivo, and of forming self-renewing organoids in vitro. Expression profiling of the different subpopulations sorted from normal and neoplastic mammary tissues revealed that the normal stem cell compartment is more similar to tumor cells than to their own differentiated progenies. Accordingly, Wnt signaling was found to be activated in the subpopulation encompassing norm

ORGANISM(S): Mus musculus

SUBMITTER: Claudia Gaspar 

PROVIDER: E-GEOD-40702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress