Clinical pediatric acute lymphoblastic leukemia samples after in vitro exposure to L-asparaginase
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ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER:
PROVIDER: E-GEOD-4071 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.
Fine Bernard M BM Kaspers Gertjan J L GJ Ho Minh M Loonen Anne H AH Boxer Linda M LM
Cancer research 20050101 1
To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used cDNA microarrays to obtain a genome-wide view of gene expression both at baseline and after in vitro exposure to l-asparaginase in cell lines and pediatric ALL samples. In 16 cell lines, a baseline gene expression pattern distinguished l-asparaginase sensitivity from resistance. However, for 28 pediatric ALL samples, no consistent baseline expression pattern was associated with sensitivity to l-asparaginas ...[more]
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