Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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L-asparaginase exposure in acute lymphoblastic leukemia cell lines time series

ABSTRACT: Time series of in vitro 2 IU/ml L-asparaginase exposure in acute lymphoblastic leukemia cell lines. Groups of assays that are related as part of a time series. Using regression correlation

ORGANISM(S): Homo sapiens

SUBMITTER:  

PROVIDER: E-GEOD-4072 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia.

Fine Bernard M BM   Kaspers Gertjan J L GJ   Ho Minh M   Loonen Anne H AH   Boxer Linda M LM  

Cancer research 20050101 1

To investigate the effect of l-asparaginase on acute lymphoblastic leukemia (ALL), we used cDNA microarrays to obtain a genome-wide view of gene expression both at baseline and after in vitro exposure to l-asparaginase in cell lines and pediatric ALL samples. In 16 cell lines, a baseline gene expression pattern distinguished l-asparaginase sensitivity from resistance. However, for 28 pediatric ALL samples, no consistent baseline expression pattern was associated with sensitivity to l-asparaginas  ...[more]