Histone Methylation Regulates Nephron Progenitor Cell Fate in Mice
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Samir El-Dahr
PROVIDER: E-GEOD-40742 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Histone signature of metanephric mesenchyme cell lines.
McLaughlin Nathan N Yao Xiao X Li Yuwen Y Saifudeen Zubaida Z El-Dahr Samir S SS
Epigenetics 20130718 9
The metanephric mesenchyme (MM) gives rise to nephrons, the filtering units of the mature kidney. The MM is composed of uninduced (Six2(high)/Lhx1(low)) and induced (Wnt-stimulated, Six2(low)/Lhx1(high)) cells. The global epigenetic state of MM cells is unknown, partly due to technical difficulty in isolating sufficient numbers of homogenous cell populations. We therefore took advantage of two mouse clonal cell lines representing the uninduced (mK3) and induced (mK4) metanephric mesenchyme (base ...[more]
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