High risk HPV-positive lung carcinomas: molecular evidence for a pattern of pulmonary metastasis

ABSTRACT: BACKGROUND: Infection with high-risk types of human papillomavirus (hrHPV) is associated with cervical, anogenital and oropharyngeal cancers. A role for hrHPV in lung cancer has been proposed, although previous reports on the contribution of hrHPV infection to lung cancer have provided contradictory results. The current study evaluated hrHPV prevalence in lung tumor specimens of different histological subtypes in a Western study population using a validated test algorithm for hrHPV detection in formalin-fixed paraffin-embedded (FFPE) tumor specimen (i.e., GP5+6+-PCR and p16INK4A immunohistochemistry). MATERIALS AND METHODS: Tumor tissue specimens from 228 lung cancer patients were subjected to GP5+6+-PCR and p16INK4A immunohistochemistry. hrHPV-positive tumors were further characterized

ORGANISM(S): Homo sapiens

SUBMITTER: Daoud Sie 

PROVIDER: E-GEOD-40777 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress