Usp44 binds centrin to regulate centrosome positioning and suppress tumorigenesis

ABSTRACT: Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy through restraining the activity of the anaphase-promoting complex (APC). USP44 was identified as a key regulator of APC activation that maintains the association of MAD2 with the APC co-activator Cdc20. However, the physiological importance of USP44 and its impact on cancer biology are unknown. Here, we show that USP44 is required to prevent tumors in mice and is frequently down-regulated in human lung cancer. USP44 inhibits chromosome segregation errors independently of its role in the mitotic checkpoint by regulating proper centrosome separation, positioning, and mitotic spindle geometry, functions that require direct binding

ORGANISM(S): Homo sapiens

SUBMITTER: Alexey Leontovich 

PROVIDER: E-GEOD-40791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress