Impaired TLR3-mediated immune responses from macrophages of patients chronically infected with Hepatitis C virus

ABSTRACT: Hepatitis C virus (HCV) is the most common chronic blood-borne infection in the United States with the majority of patients becoming chronically infected and a subset (20%) progressing to cirrhosis and hepatocellular carcinoma. Individual variations in immune responses may help define successful resistance to infection with HCV. We have examined the immune response in primary macrophages from patients who have spontaneously cleared HCV (viral load negative, VL-, n = 37) compared to HCV genotype 1 chronically infected (VL+) subjects (n=32) and found that macrophages from VL- subjects have an elevated baseline expression of Toll-like receptor 3 (TLR3). Macrophages from HCV patients were stimulated ex vivo through the TLR3 pathway and assessed using gene expression arrays and pathway analysis

ORGANISM(S): Homo sapiens

SUBMITTER: Ruth Montgomery 

PROVIDER: E-GEOD-40812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress