KDM2B binds CpG islands and modulates recruitment of Ring1b

ABSTRACT: CpG island elements are associated with most mammalian gene promoters, yet how they contribute to gene regulation remains poorly understood. Recently it has become clear that a subset of CpG islands in embryonic stem cells can act as polycomb response elements and are recognized by the polycomb silencing systems to regulate the expression of genes involved in pluripotency and early developmental transcription programs. How CpG islands function mechanistically as nucleation sites for polycomb repressive complexes remains unknown. Here we discover that the KDM2B protein, by virtue of its ZF-CxxC DNA binding domain, specifically recognizes non-methylated DNA in CpG islands elements genome-wide. Through a physical interaction with the polycomb repressive complex 1 (PRC1), KDM2B targets PRC1 to

ORGANISM(S): Mus musculus

SUBMITTER: Ian Sudbery 

PROVIDER: E-GEOD-40860 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress