Expression of the placental transcriptome in fetal growth restriction in the Baboon is Dependent on Fetal Sex

ABSTRACT: Fetal growth restriction (FGR) develops when fetal nutrient availability is compromised and increases the risk for perinatal complications and predisposes for offspring obesity, diabetes and cardiovascular disease later in life. Emerging evidence implicates changes in placental function in altered fetal growth and the subsequent development of adult disease. The susceptibility for disease in response to an adverse intrauterine environment differs distinctly between boys and girls, with girls typically having better outcomes. Here, we test the hypothesis that regulation of the placental transcriptome by moderate nutrient reduction is dependent on fetal sex. We used a non-human primate model of FGR in which maternal global food intake is reduced by 30% starting at gestational day (GD) 30.

ORGANISM(S): Papio hamadryas

SUBMITTER: Laura Cox 

PROVIDER: E-GEOD-40878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress