The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells

ABSTRACT: We employed the DamID technique to systematically map the genomic distribution of all canonical somatic H1 subtypes (H1.1-H1.5) in human IMR90 cells. Human cells contain up to eleven histone H1 proteins, with different spatial and temporal expression patterns. These include five canonical, replication-dependent somatic H1 subtypes (H1.1, H1.2, H1.3, H1.4 and H1.5). Despite being a key chromatin component, the genomic distribution of the somatic canonical H1 subtypes is still unknown and their role in chromatin related processes has so far remained elusive. Here we employed a DamID approach to map for the first time the genomic localization of all somatic canonical H1 subtypes in human cells. Our integrative analysis reveals novel insights into H1 subtype distribution and uncovers functio

ORGANISM(S): Homo sapiens

SUBMITTER: Kinga Kamieniarz 

PROVIDER: E-GEOD-40886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress