Ocular fibroblast types differ in their mRNA profiles - implications for fibrosis prevention after aqueous shunt implantation

ABSTRACT: Surgical glaucoma therapy is characterized by implantation of an aqueous shunt either draining into the extraocular Tenon’s space or the intraocular suprachoroidal space. In both cases the long term drainage is hampered by fibrotic reactions around the outflow region of the shunt. The prevention of fibrosis should extend the operating life of the shunt. For an aqueous shunt draining from the anterior chamber into the choroidal space fibroblasts from the choroidea and/or the sclera are most likely responsible for a fibrotic response around the outflow region of such a shunt. A detailed characterization of fibroblasts derived from choroidea and sclera should provide information whether a fibrosis reaction can be inhibited by cell type specific agents. Therefore, we have decided to generate

ORGANISM(S): Homo sapiens

SUBMITTER: Joerg Mostertz 

PROVIDER: E-GEOD-40929 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress