Impact of STAT5 dosage and binding location on genetic and biological programs activated in mouse mammary epithelium during pregnancy.

ABSTRACT: The transcription factor STAT5 has long been recognized as an important mediator of prolactin induced mammary development during pregnancy. We have used mouse genetics and genome-wide analyses to determine how altering concentrations of STAT5A and STAT5B impacts different target promoters. Examination of genome-wide STAT5A, STAT5B, PolII and H3K4me3 in wild type (AABB) and Stat5a-null (BB) mammary tissues.

ORGANISM(S): Mus musculus

SUBMITTER: Keunsoo Kang 

PROVIDER: E-GEOD-40930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress