Quaking is a global regulator of muscle-specific alternative splicing in vertebrates [siRNA data]

ABSTRACT: This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative splicing contributes to muscle development and differentiation, but the complete set of muscle splicing factors and their combinatorial interactions are not known. Previously work identifies ACUAA (STAR motif) as an enriched sequence near muscle-specific alternative exons such as Capzb exon 9. We did mass spectrometry of proteins selected by wild type and mutant Capzb intron 9 RNA affinity chromatography, and identified Quaking (Qk), a protein known to regulate mRNA function through ACUAA motifs in

ORGANISM(S): Mus musculus

SUBMITTER: Manny Ares 

PROVIDER: E-GEOD-40961 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress