SIRT3 functions in the nucleus in the control of stress-related gene expression.

ABSTRACT: SIRT3 is a member of the Sir2 family of NAD+-dependent protein deacetylases that promotes longevity in many organisms. The processed, short form of SIRT3 is a well-established mitochondrial protein whose deacetylase activity regulates various metabolic processes. However, the presence of full-length (FL) SIRT3 in the nucleus and its functional importance remains controversial. Our previous studies demonstrated that nuclear FL-SIRT3 functions as a histone deacetylase and is transcriptionally repressive when artificially recruited to a reporter gene. Here, we report that nuclear FL-SIRT3 is subjected to rapid degradation upon cellular stress, including oxidative stress and UV-irradiation, whereas the mitochondrial, processed form is unaffected. FL-SIRT3 degradation is mediated by the ubiquit

ORGANISM(S): Homo sapiens

SUBMITTER: Roberto Bonasio 

PROVIDER: E-GEOD-41000 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress