Microarray analysis of gene response to contaminant accumulation in wild largescale suckers

ABSTRACT: Toxic compounds such as organochlorine pesticides (OCs), polychlorinated biphenyls (PCBs), and polybrominated diphenyl ether flame retardants (PBDEs) have been detected in fish, birds, and aquatic mammals that live in the Columbia River or use the river as a food source. We developed a custom microarray for largescale suckers (Catostomus macrocheilus) and used it to investigate the molecular effects of contaminant exposure on wild fish in the Columbia River. Using Significance Analysis of Microarrays (SAM) we identified 72 probes representing 69 unique genes with expression patterns that correlated with hepatic tissue levels of OCs, PCBs, or PBDEs. These genes were involved in many biological processes previously shown to respond to contaminant exposure, including drug and lipid metabolism

ORGANISM(S): Catostomus macrocheilus

SUBMITTER: Alvina Mehinto 

PROVIDER: E-GEOD-41016 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress