Sca-1 is an early-response target of histone deacetylase inhibitors and marks hematopoietic cells with enhanced function

ABSTRACT: Expression profiles of LSK cells stimulated for 24h in the presence or in the absence of of valproic acid (VPA) The molecular process that underlies the biological effects of valproic acid (VPA), a widely used histone deacetylase inhibitor, on HSPCs was investigated by studying the early-response genes of VPA. Genome-wide gene expression studies revealed overrepresentation of genes involved in glutathione metabolism, receptor and signal transducer activity and changes in the HSPCs surface profile following short, 24h VPA treatment. Sca-1, a well-known and widely used stem cell surface marker, was identified as a prominent VPA target.VPA strongly preserved Sca-1 expression on LSK cells, but also re-activated Sca-1 on committed progenitor cells that were Sca-1 negative, thereby reverting the

ORGANISM(S): Mus musculus

SUBMITTER: Leonid Bystrykh 

PROVIDER: E-GEOD-41020 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress