A predictive signature gene set for discriminating active from latent TB in Warao Amerindian children

ABSTRACT: While blood transcriptional profiling has improved diagnosis and understanding of disease pathogenesis of adult tuberculosis (TB), no studies applying gene expression profiling of children with TB have been described so far. In this study, we have compared whole blood gene expression in childhood TB patients, as well as in healthy latently infected (LTBI) and uninfected (HC) children in a cohort of Warao Amerindians in the Delta Amacuro in Venezuela. We identified a 116-gene signature set by means of random forest analysis that showed an average prediction error of 11% for TB vs. LTBI and for TB vs. LTBI vs. HC in our dataset. Furthermore, a minimal set of only 9 genes showed a significant predictive value for all previously published adult studies using whole blood gene expression, with a

ORGANISM(S): Homo sapiens

SUBMITTER: Aldert Zomer 

PROVIDER: E-GEOD-41055 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress