H1N1 influenza A/New Caledonia/20/1999 time series in monocyte-derived dendritic cells

ABSTRACT: Genome-wide gene expression patterns were measured in human monocyte-derived dendritic cells (DCs) infected in vitro with seasonal H1N1 influenza A/New Caledonia/20/1999. To provide a mechanistic explanation for the timing of gene expression changes over the first 12 hours post-infection, we developed a statistically rigorous enrichment approach integrating genome-wide expression kinetics and time-dependent promoter analysis. Our approach, TI me-Dependent Activity Linker (TIDAL), generates a regulatory network that connects transcription factors associated with each temporal phase of the response into a coherent linked cascade. TIDAL infers 12 transcription factors and 32 regulatory connections that drive the antiviral response to influenza. To demonstrate the generality of this app

ORGANISM(S): Homo sapiens

SUBMITTER: Juilee Thakar 

PROVIDER: E-GEOD-41067 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress