Expression data after irradiating mMSCs for 12 hours with broadband terahertz source

ABSTRACT: We report that terahertz (THz) irradiation of mouse mesenchymal stem cells with a pulsed broadband (centered at 10 THz) source, or a single-frequency, 2.52 THz, (SF) laser source, both with weak average power (<1mW/cm2), results in specific heterogenic changes in gene expression. The insignificant differential expression of heat shock and stress related genes as well as our temperature measurements imply a non-thermal response. The microarray survey and RT-PCR experiments demonstrate that at different irradiation conditions distinct groups of genes are activated. Stem cells irradiated for 12 hours with the broadband THz source exhibit an accelerated differentiation toward adipose phenotype, while the 2-hour (broadband or SF) irradiation affects genes transcriptionally active in pluripotent

ORGANISM(S): Mus musculus

SUBMITTER: Boian Alexandrov 

PROVIDER: E-GEOD-41084 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress