Gene expression profile in the spleen of mice fed Lactobacillus brevis KB290

ABSTRACT: Lactic acid bacteria confer a variety of health benefits. Here we investigate the mechanisms by which Lactobacillus brevis KB290 enhances cell-mediated cytotoxic activity. We fed a diet containing KB290 (3 M-CM-^W 10^9 colony-forming units/g) , or potato starch, to 9-week-old female BALB/c mice for 1, 4, 7, or 14 days and examined the cytotoxic activity of splenocytes was measured. RNA was extracted from the spleen and analyzed for gene expression by DNA microarray. KB290 enhanced the cell-mediated cytotoxic activity of splenocytes. The Gene Ontology (GO) terms related to immune process were significantly enriched in up-regulated gene set for 7 days and the GO terms related to cellular process were enriched in down-regulated gene set on days 4 and 7. Among the GO terms related to immune pr

ORGANISM(S): Mus musculus

SUBMITTER: Yuichiro Fukui 

PROVIDER: E-GEOD-41127 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress