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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptome analysis of the injected mice overexpressing TFEB specifically in liver

ABSTRACT: In order to identify the effects of TFEB overexpression on the liver transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the injected mice For the analysis on the injected mice overexpressing TFEB, total RNA was extracted from the liver of three mice; RNA extracted from the liver of not-injected mice was used as control.

ORGANISM(S): Mus musculus

SUBMITTER: Rossella De Cegli

PROVIDER: E-GEOD-41139 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from injected mice overexpressing TFEB specifically in liver

Project description:In order to identify the effects of transcription factor EB (TFEB) overexpression on the liver transcriptome, we performed Affymetrix GeneChip hybridization experiments on injected mice overexpressing TFEB specifically in the liver. For the analysis of the injected mice overexpressing TFEB, total RNA was extracted from the liver of three mice. RNA extracted from the liver of 3 not-injected mice was used as a control.

2013-04-20 | E-GEOD-35015 | biostudies-arrayexpress

Transcriptome analysis of the injected Ppara-KO mice overexpressing TFEB specifically in liver

Project description:Expression data from Ppara (peroxisome proliferator activated receptor alpha) KO mice injected with TFEB specifically in liver. In order to identify the effects of TFEB overexpression together with Ppara absence on the liver transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the injected mice For the analysis on the injected Ppara-KO mice overexpressing TFEB, total RNA was extracted from the liver of three mice; RNA extracted from the liver of not-injected mice was used as control.

2013-04-20 | E-GEOD-41140 | biostudies-arrayexpress

Transcriptome analysis of liver samples from PPARa KO and control mice injected with HDAd-TFEB

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-04-20 | E-GEOD-41141 | biostudies-arrayexpress

Expression data from wild-type mice starved as compared to wild-type control mice

Project description:In order to identify the effects of starvation on the liver transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the starved mice Transcriptome analysis of the starved mice For the analysis on the starved mice,total RNA was extracted from the liver of two mice; RNA extracted from the liver of two wt mice was used as control.

2013-04-20 | E-GEOD-36510 | biostudies-arrayexpress

Transcriptome analysis of the injected Ppara-KO mice overexpressing TFEB specifically in liver

2013-04-20 | GSE41140 | GEO

Expression data from injected mice overexpressing TFEB specifically in liver

2013-04-20 | GSE35015 | GEO

Transcriptome analysis of the injected mice overexpressing TFEB specifically in liver

Project description:In order to identify the effects of TFEB overexpression on the liver transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for the injected mice

2013-04-20 | GSE41139 | GEO

Expression data from transgenic mice overexpressing TFEB specifically in liver

Project description:In order to identify the effects of TFEB overexpression on liver transcriptome, we performed Affymetrix Gene-Chip hybridization experiments for transgenic mice at P9 Transcriptome analysis of transgenic mice overexpressing TFEB specifically in liver

2020-12-17 | GSE77481 | GEO

Identification of TFEB regulated genes during in vitro RGC to EPC differentiation (RNA-seq)

Project description:The largest germinal niche of the adult mammal brain locates at the ventricular zone (VZ), which is made up of adult neural stem cells (NSCs) and multiciliated ependymal cells (EPCs). Both NSCs and EPCs derive from radial glia (RG), whereas the transcriptomic dynamic changes of the cell fate continuum remain elusive. Here, we identified a key transcription factor TFEB that is important during EPC differentiation. We knockdown TFEB using siRNA and check gene expression changes upon TFEB depletion by RNA-seq.

2024-04-21 | E-MTAB-13856 | biostudies-arrayexpress

TFEB AND TFE3 DRIVE KIDNEY CYSTOGENESIS AND TUMORIGENESIS

Project description:Birt-Hogg-Dubè (BHD) syndrome is an inherited condition caused by loss-of-function mutations in the gene encoding the tumor-suppressor protein folliculin (FLCN) and frequently associated with kidney cysts and cancer. FLCN acts as a negative regulator of TFEB and TFE3 transcription factors, master controllers of lysosomal biogenesis and autophagy, by enabling their phosphorylation by the mechanistic Target Of Rapamycin Complex 1 (mTORC1). We previously showed that deletion of TFEB rescued the renal cystic phenotype of kidney-specific Flcn KO mice. Using Flcn/TFEB/TFE3 double and triple KO mice we now show that both TFEB and TFE3 contribute, in a differential and cooperative manner, to kidney cystogenesis. Importantly, silencing of either TFEB or TFE3 rescued tumorigenesis in patient-derived xenografts (PDXs) generated from a kidney tumor of a BHD patient. Furthermore, transcriptome analyses performed in transgenic mice, PDXs and patient tumor samples revealed TFEB/TFE3 downstream targets that may contribute to their tumorigenic activity. Our findings demonstrate in disease-relevant models that TFEB and TFE3 are key drivers of kidney tumorigenesis and suggest novel therapeutic strategies based on the inhibition of these transcription factors.

2023-04-04 | PXD035450 | Pride

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